Expression profile of microRNAs in the testes of patients with Klinefelter syndrome

Klinefelter syndrome (KS) is the most common sex chromosome aneuploidy. Typical characteristics of KS is oligozoospermia. Although several studies have described the natural history of the degenerative process germ cells in patients with KS, the molecular mechanisms that initiate this process is not well marked.

MicroRNA (miRNA) -mediated post-transcriptional control mechanisms has been increasingly recognized as an important regulator of spermatogenesis; However, only a few studies have evaluated the role of miRNAs in gonadal failure patients.

Here, we describe the differential expression profiles of miRNAs in samples of testicular tissue taken from patients with KS. We analyzed samples of testicular tissue from 4 KS patients and 5 control patients (obstructive azoospermia) through generation sequencing, which can provide information about the mechanisms involved in the degeneration of germ cells. Typical differential expression profiles for 166 miRNAs identified in KS patients: 66 were upregulated and 100 downregulated.

A interactome analysis conducted for 7 of the 20 miRNAs upregulated and downregulated. The results showed that the target gene is involved in the development process, proliferation, and differentiation of spermatogenesis, which may explain their role in the development of infertility. This is the first report of a miRNA expression profiles generated from samples of testicular tissue KS patients.

 Expression profile of microRNAs in the testes of patients with Klinefelter syndrome
Expression profile of microRNAs in the testes of patients with Klinefelter syndrome

MicroRNA profiles altered in neonatal pigs following the milk glands after giving birth to a nursing infant formula

Postnatal dietary modulation of microRNAs (miRNAs) and the effect on miRNA-mRNA interactions in tissues remains unknown. This study aimed to investigate whether dietary factors (formula vs. breastfeeding) affected milk miRNA expression and to determine whether these changes coincide with changes in mammary gland development in neonatal piglets. Female Yorkshire / Duroc pig pigs fed milk or milk- or soy-based infant formula milk cow (from postnatal day 2 days 21; n = 6 / group).

Different miRNAs expressed milk is determined by using miRNA profiles, followed by miRNA and mRNA expression characterized by reverse-transcription quantitative polymerase chain reaction. Milk and soy formulas reduce the expression of miR-1, -128, -133a, -193b, -206 and -27a; Mirna modified mRNA down-regulation of gene expression (eg, Ccnd1, Tgfb3, Igf1r and Tbx3) consistent with increased cell proliferation and reduced apoptosis in the developing mammary gland.

Interestingly, down-regulation of miR-1, -128 and -27a also correlates with increased gene mRNA encoding such Hmgcr Hmgcs and cholesterol synthesis in the mammary gland in response to lower levels of cholesterol circulating. feeding formula milk affected miRNA profile in neonatal pigs, along with increased cell proliferation and gene expression of cholesterol synthesis, indicating the beginning of the nutritional modulation of miRNAs can contribute to the regulation of cholesterol homeostasis status and the proliferation of mammary glands develop during infancy.

Pooled Virus Library of all Lenti-miR microRNA Precursor Constructs [4 virus aliquots]

PMIRHPLVA-1 4 virus aliquots
EUR 5974.8

Scramble control hairpin in pCDH-CMV-MCS-EF1-copGFP (CD511B-1)

PMIRH000PA-1 Bacterial Streak
EUR 787.2

pGreenPuro Scramble Hairpin Control - Construct (for shRNAs and miRZips)

MZIP000-AA-1 Miniprep DNA
EUR 820.8

pGreenPuro Scramble Hairpin Control - Construct (for shRNAs and miRZips)

MZIP000-PA-1 Bacterial Streak
EUR 787.2

MicroRNA Isolation Kit

KS341025 1 kit
EUR 307.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

pGreenFire1-LXRE in SREBP1c (virus)

TR100VA-P >2 x 10^6 IFUs
EUR 943.2

pGreenFire1-LXRE in ApoA1(virus)

TR104VA-P >2 x 10^6 IFUs
EUR 943.2

pGreenFire1-LXRE in Cyp7A1(virus)

TR105VA-P >2 x 10^6 IFUs
EUR 943.2

pGreenFire1-LXRE in ABCA1(virus)

TR106VA-P >2 x 10^6 IFUs
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pGreenFire1-LXRE in ABCG1(virus)

TR107VA-P >2 x 10^6 IFUs
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pGreenFire1-LXRE in ApoE(virus)

TR108VA-P >2 x 10^6 IFUs
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pGreenFire1-LXRE in CETP(virus)

TR109VA-P >2 x 10^6 IFUs
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Cancer MicroRNA qPCR Array

RA610A-1 10 profiles
EUR 1406.4

pGreenFire1-LXRE in LXR alpha (virus)

TR102VA-P >2 x 10^6 IFUs
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MicroRNA Precursor Pooled Plasmid Library

PMIRHPLPA-1 1 aliquot plasmid DNA
EUR 60

SanPrep Column microRNA Miniprep Kit

SK8811 50prep
EUR 151.32

Stem Cell MicroRNA Profiling Panel

RA620A-1 10 profiles
EUR 1406.4

Virus Measles Virus (MeV) Protein

abx670263-1ml 1 ml
EUR 543.6

Bovine Leukemia Virus(Leukemia Virus)

QY-E60121 96T
EUR 511.2

Virus Respiratory Syncytial Virus (RSV) Protein

abx670078-01mg 0.1 mg
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Virus Hepatitis A Virus (HAV) Protein

abx670259-1ml 1 ml
EUR 427.2

Virus Varicella Zoster Virus (VZV) Protein

abx670269-1ml 1 ml
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Virus West Nile Virus (WNV) Protein

abx670276-100ug 100 ug
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Virus Yellow Fever Virus (YFV) Protein

abx670277-100ug 100 ug
EUR 644.4

miRZip-100 anti-miR-100 microRNA construct, for distribution in Taiwan

MZIP100-AA-1 Miniprep DNA
EUR 859.2

miRZip-150 anti-miR-150 microRNA construct, for distribution in Taiwan

MZIP150-AA-1 Miniprep DNA
EUR 820.8

miRZip-205 anti-miR-205 microRNA construct, for distribution in Taiwan

MZIP205-AA-1 Miniprep DNA
EUR 820.8

miRZip-30c anti-miR-30c microRNA construct, for distribution in Taiwan

MZIP30c-AA-1 Miniprep DNA
EUR 820.8

Human pre-microRNA Expression Construct Lenti-miR-23b in CD511B-1

PMIRH23b-onlyPA-1 Bacterial Streak
EUR 820.8

Mumps Virus

DAG202 1 ml
EUR 837.6

EBV Virus

G229 10 ml
EUR 882

MicroRNA precursor pooled library, HT prepackaged

PMIRHPLVAHT-1 10 virus aliquots
EUR 12042

Human microRNA-210(miR-210)ELISA

QY-E05678 96T
EUR 433.2

hsa-miRNome MicroRNA Profiling Kit [Human]

RA660A-1 20 profiles
EUR 2212.8

mmu-miRNome MicroRNA Profiling Kit [Mouse]

RA670A-1 20 profiles
EUR 2046

rno-miRNome MicroRNA Profiling Kit [Rat]

RA680B-1 20 complete profiles
EUR 2006.4

Chicken Virus Enteritis (Virus Enteritis) ELISA Kit

abx052451-96tests 96 tests
EUR 801.6

Virus Grapevine Virus A (GVA) ELISA Kit

abx055777-96tests 96 tests
EUR 801.6

Virus Grapevine Virus B (GVB) ELISA Kit

abx055779-96tests 96 tests
EUR 801.6

Virus Grapevine Virus D (GVD) ELISA Kit

abx055781-96tests 96 tests
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Virus Parainfluenza Virus 1 (HPIV-1) Protein

abx670265-1ml 1 ml
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Virus Parainfluenza Virus 2 (HPIV-2) Protein

abx670266-1ml 1 ml
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Virus Parainfluenza Virus 3 (HPIV-3) Protein

abx670267-1ml 1 ml
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Rabbit Anti-Mumps virus (Enders) Virus antiserum

MUMS11-S 0.1 ml
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Rabbit Anti-Mumps virus (Enders) Virus antiserum

MUMS11-SB 0.5 ml
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Monoclonal Anti-Mumps virus (Enders) Virus IgG

MUMS12-M 100 ul
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Human pre-microRNA Expression Construct Lenti-miR-150, for distribution in Taiwan

PMIRH150AA-1 Miniprep DNA
EUR 820.8

Human pre-microRNA Expression Construct Lenti-miR-19a in CD513B-1 MI0000073

PMIRH19a-onlyPA-1 Bacterial Streak
EUR 820.8

miRZip-1 anti-miR-1 microRNA construct

MZIP1-PA-1 Bacterial Streak
EUR 820.8

miRZip-100 anti-miR-100 microRNA construct

MZIP100-PA-1 Bacterial Streak
EUR 820.8

miRZip-101 anti-miR-101 microRNA construct

MZIP101-PA-1 Bacterial Streak
EUR 820.8

miRZip-103 anti-miR-103 microRNA construct

MZIP103-PA-1 Bacterial Streak
EUR 820.8

miRZip-106a anti-miR-106a microRNA construct

MZIP106a-PA-1 Bacterial Streak
EUR 820.8

miRZip-106b anti-miR-106b microRNA construct

MZIP106b-PA-1 Bacterial Streak
EUR 820.8

miRZip-107 anti-miR-107 microRNA construct

MZIP107-PA-1 Bacterial Streak
EUR 820.8

miRZip-10a anti-miR-10a microRNA construct

MZIP10a-PA-1 Bacterial Streak
EUR 820.8

miRZip-10b anti-miR-10b microRNA construct

MZIP10b-PA-1 Bacterial Streak
EUR 820.8

miRZip-122 anti-miR-122 microRNA construct

MZIP122-PA-1 Bacterial Streak
EUR 820.8

miRZip-122a anti-miR-122a microRNA construct

MZIP122a-PA-1 Bacterial Streak
EUR 820.8

miRZip-124 anti-miR-124 microRNA construct

MZIP124-PA-1 Bacterial Streak
EUR 820.8

miRZip-125b anti-miR-125b microRNA construct

MZIP125b-AA-1 Miniprep DNA
EUR 820.8

miRZip-125b anti-miR-125b microRNA construct

MZIP125b-PA-1 Bacterial Streak
EUR 820.8

miRZip-1275 anti-miR-1275 microRNA construct

MZIP1275-PA-1 Bacterial Streak
EUR 820.8

miRZip-128 anti-miR-128 microRNA construct

MZIP128-PA-1 Bacterial Streak
EUR 820.8

miRZip-1290 anti-miR-1290 microRNA construct

MZIP1290-PA-1 Bacterial Streak
EUR 820.8

miRZip-130a anti-miR-130a microRNA construct

MZIP130a-PA-1 Bacterial Streak
EUR 820.8

miRZip-130b anti-miR-130b microRNA construct

MZIP130b-PA-1 Bacterial Streak
EUR 820.8

miRZip-132 anti-miR-132 microRNA construct

MZIP132-PA-1 Bacterial Streak
EUR 820.8

miRZip-133a anti-miR-133a microRNA construct

MZIP133a-PA-1 Bacterial Streak
EUR 820.8

miRZip-133b anti-miR-133b microRNA construct

MZIP133b-PA-1 Bacterial Streak
EUR 820.8

miRZip-134 anti-miR-134 microRNA construct

MZIP134-PA-1 Bacterial Streak
EUR 820.8

miRZip-135b anti-miR-135b microRNA construct

MZIP135b-PA-1 Bacterial Streak
EUR 820.8

miRZip-136 anti-miR-136 microRNA construct

MZIP136-PA-1 Bacterial Streak
EUR 820.8

miRZip-137 anti-miR-137 microRNA construct

MZIP137-PA-1 Bacterial Streak
EUR 820.8

miRZip-138 anti-miR-138 microRNA construct

MZIP138-PA-1 Bacterial Streak
EUR 820.8

miRZip-141 anti-miR-141 microRNA construct

MZIP141-PA-1 Bacterial Streak
EUR 820.8

miRZip-143 anti-miR-143 microRNA construct

MZIP143-PA-1 Bacterial Streak
EUR 820.8

miRZip-144 anti-miR--144 microRNA construct

MZIP144-PA-1 Bacterial Streak
EUR 820.8

miRZip-145 anti-miR-145 microRNA construct

MZIP145-PA-1 Bacterial Streak
EUR 820.8

miRZip-146a anti-miR-146a microRNA construct

MZIP146a-PA-1 Bacterial Streak
EUR 820.8

miRZip-147 anti-miR-147 microRNA construct

MZIP147-PA-1 Bacterial Streak
EUR 820.8

miRZip-148a anti-miR-148a microRNA construct

MZIP148a-PA-1 Bacterial Streak
EUR 820.8

miRZip-149 anti-miR-149 microRNA construct

MZIP149-PA-1 Bacterial Streak
EUR 820.8

miRZip-150 anti-miR-150 microRNA construct

MZIP150-PA-1 Bacterial Streak
EUR 820.8

miRZip-152 anti-miR-152 microRNA construct

MZIP152-PA-1 Bacterial Streak
EUR 820.8

miRZip-153 anti-miR-153 microRNA construct

MZIP153-PA-1 Bacterial Streak
EUR 820.8

miRZip-154 anti-miR-154 microRNA construct

MZIP154-PA-1 Bacterial Streak
EUR 820.8

miRZip-155 anti-miR-155 microRNA construct

MZIP155-PA-1 Bacterial Streak
EUR 820.8

miRZip-15a anti-miR-15a microRNA construct

MZIP15a-PA-1 Bacterial Streak
EUR 820.8

miRZip-15b anti-miR-15b microRNA construct

MZIP15b-PA-1 Bacterial Streak
EUR 820.8

miRZip-16 anti-miR-16 microRNA construct

MZIP16-PA-1 Bacterial Streak
EUR 820.8

miRZip-17 anti-miR-17 microRNA construct

MZIP17-AA-1 Miniprep DNA
EUR 820.8

miRZip-17 anti-miR-17 microRNA construct

MZIP17-PA-1 Bacterial Streak
EUR 820.8

miRZip-181a anti-miR-181a microRNA construct

MZIP181a-AA-1 Miniprep DNA
EUR 820.8

miRZip-181a anti-miR-181a microRNA construct

MZIP181a-PA-1 Bacterial Streak
EUR 820.8

miRZip-181b anti-miR-181b microRNA construct

MZIP181b-PA-1 Bacterial Streak
EUR 820.8

miRZip-182 anti-miR-182 microRNA construct

MZIP182-AA-1 Miniprep DNA
EUR 820.8

miRZip-182 anti-miR-182 microRNA construct

MZIP182-PA-1 Bacterial Streak
EUR 820.8

miRZip-183 anti-miR-183 microRNA construct

MZIP183-PA-1 Bacterial Streak
EUR 820.8

miRZip-184 anti-miR-184 microRNA construct

MZIP184-PA-1 Bacterial Streak
EUR 820.8

miRZip-185 anti-miR-185 microRNA construct

MZIP185-PA-1 Bacterial Streak
EUR 820.8

miRZip-186 anti-miR-186 microRNA construct

MZIP186-PA-1 Bacterial Streak
EUR 820.8

miRZip-187 anti-miR-187 microRNA construct

MZIP187-PA-1 Bacterial Streak
EUR 820.8

miRZip-18a anti-miR-18a microRNA construct

MZIP18a-PA-1 Bacterial Streak
EUR 820.8

miRZip-18b anti-miR-18b microRNA construct

MZIP18b-PA-1 Bacterial Streak
EUR 820.8

miRZip-190 anti-miR-190 microRNA construct

MZIP190-PA-1 Bacterial Streak
EUR 820.8

miRZip-1908 anti-miR-1908 microRNA construct

MZIP1908-PA-1 Bacterial Streak
EUR 820.8

miRZip-192 anti-miR-192 microRNA construct

MZIP192-PA-1 Bacterial Streak
EUR 820.8

miRZip-193b anti-miR-193b microRNA construct

MZIP193b-PA-1 Bacterial Streak
EUR 820.8

miRZip-194 anti-miR-194 microRNA construct

MZIP194-PA-1 Bacterial Streak
EUR 820.8

miRZip-195 anti-miR-195 microRNA construct

MZIP195-PA-1 Bacterial Streak
EUR 820.8

miRZip-196a anti-miR-196a microRNA construct

MZIP196a-AA-1 Miniprep DNA
EUR 820.8

miRZip-196a anti-miR-196a microRNA construct

MZIP196a-PA-1 Bacterial Streak
EUR 820.8

miRZip-196b anti-miR-196b microRNA construct

MZIP196b-AA-1 Miniprep DNA
EUR 820.8

miRZip-196b anti-miR-196b microRNA construct

MZIP196b-PA-1 Bacterial Streak
EUR 820.8

miRZip-198 anti-miR-198 microRNA construct

MZIP198-PA-1 Bacterial Streak
EUR 820.8

miRZip-19a anti-miR-19a microRNA construct

MZIP19a-PA-1 Bacterial Streak
EUR 820.8

miRZip-19b anti-miR-19b microRNA construct

MZIP19b-PA-1 Bacterial Streak
EUR 820.8

miRZip-200a anti-miR-200a microRNA construct

MZIP200a-PA-1 Bacterial Streak
EUR 820.8

miRZip-200b anti-miR-200b microRNA construct

MZIP200b-PA-1 Bacterial Streak
EUR 820.8

miRZip-200c anti-miR-200c microRNA construct

MZIP200c-PA-1 Bacterial Streak
EUR 820.8

miRZip-202 anti-miR-202 microRNA construct

MZIP202-PA-1 Bacterial Streak
EUR 820.8

miRZip-203 anti-miR-203 microRNA construct

MZIP203-PA-1 Bacterial Streak
EUR 820.8

miRZip-204 anti-miR-204 microRNA construct

MZIP204-PA-1 Bacterial Streak
EUR 820.8

miRZip-205 anti-miR-205 microRNA construct

MZIP205-PA-1 Bacterial Streak
EUR 820.8

miRZip-206 anti-miR-206 microRNA construct

MZIP206-PA-1 Bacterial Streak
EUR 820.8

miRZip-20a anti-miR-20a microRNA construct

MZIP20a-PA-1 Bacterial Streak
EUR 820.8

miRZip-20b anti-miR-20b microRNA construct

MZIP20b-PA-1 Bacterial Streak
EUR 820.8

miRZip-21 anti-miR-21 microRNA construct

MZIP21-PA-1 Bacterial Streak
EUR 820.8

miRZip-210 anti-miR-210 microRNA construct

MZIP210-PA-1 Bacterial Streak
EUR 820.8

miRZip-211 anti-miR-211 microRNA construct

MZIP211-PA-1 Bacterial Streak
EUR 820.8


placenta-derived exosomes play an important role in cellular communication both in the mother and fetus. concentration and their composition is modified in some disorders of pregnancy, such as gestational diabetes mellitus (GDM). Isolation and characterization of placental exosomes from serum, plasma and tissue from patients with GDM have been described previously; However, to the best of our knowledge, to date, no studies are available on placental exosomes isolated from the urine of patients with GDM.