Expression profile of microRNAs in the testes of patients with Klinefelter syndrome
Klinefelter syndrome (KS) is the most common sex chromosome aneuploidy. Typical characteristics of KS is oligozoospermia. Although several studies have described the natural history of the degenerative process germ cells in patients with KS, the molecular mechanisms that initiate this process is not well marked.
MicroRNA (miRNA) -mediated post-transcriptional control mechanisms has been increasingly recognized as an important regulator of spermatogenesis; However, only a few studies have evaluated the role of miRNAs in gonadal failure patients.
Here, we describe the differential expression profiles of miRNAs in samples of testicular tissue taken from patients with KS. We analyzed samples of testicular tissue from 4 KS patients and 5 control patients (obstructive azoospermia) through generation sequencing, which can provide information about the mechanisms involved in the degeneration of germ cells. Typical differential expression profiles for 166 miRNAs identified in KS patients: 66 were upregulated and 100 downregulated.
A interactome analysis conducted for 7 of the 20 miRNAs upregulated and downregulated. The results showed that the target gene is involved in the development process, proliferation, and differentiation of spermatogenesis, which may explain their role in the development of infertility. This is the first report of a miRNA expression profiles generated from samples of testicular tissue KS patients.
MicroRNA profiles altered in neonatal pigs following the milk glands after giving birth to a nursing infant formula
Postnatal dietary modulation of microRNAs (miRNAs) and the effect on miRNA-mRNA interactions in tissues remains unknown. This study aimed to investigate whether dietary factors (formula vs. breastfeeding) affected milk miRNA expression and to determine whether these changes coincide with changes in mammary gland development in neonatal piglets. Female Yorkshire / Duroc pig pigs fed milk or milk- or soy-based infant formula milk cow (from postnatal day 2 days 21; n = 6 / group).
Different miRNAs expressed milk is determined by using miRNA profiles, followed by miRNA and mRNA expression characterized by reverse-transcription quantitative polymerase chain reaction. Milk and soy formulas reduce the expression of miR-1, -128, -133a, -193b, -206 and -27a; Mirna modified mRNA down-regulation of gene expression (eg, Ccnd1, Tgfb3, Igf1r and Tbx3) consistent with increased cell proliferation and reduced apoptosis in the developing mammary gland.
Interestingly, down-regulation of miR-1, -128 and -27a also correlates with increased gene mRNA encoding such Hmgcr Hmgcs and cholesterol synthesis in the mammary gland in response to lower levels of cholesterol circulating. feeding formula milk affected miRNA profile in neonatal pigs, along with increased cell proliferation and gene expression of cholesterol synthesis, indicating the beginning of the nutritional modulation of miRNAs can contribute to the regulation of cholesterol homeostasis status and the proliferation of mammary glands develop during infancy.
 microRNA-21-IN-3 |
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| HY-153534 | MedChemExpress | 1 mg | EUR 2056.31 |
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Description: microRNA-21-IN-3 (compound 45) can specifically bind to the precursor of oncogenic and pro-inflammatory microRNA-21 with medium nanomolar affinity, reduce cancer cell proliferation and miR-21 levels, and can be used in antitumor research[1]. |
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 microRNA-21-IN-1 |
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| HY-146411 | MedChemExpress | 1 mg | EUR 2943.77 |
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Description: microRNA-21-IN-1 (compound 7A) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer[1]. |
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microRNA-21-IN-1 |
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| T63879-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: microRNA-21-IN-1 |
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microRNA-21-IN-1 |
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| T63879-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: microRNA-21-IN-1 |
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microRNA-21-IN-1 |
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| T63879-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: microRNA-21-IN-1 |
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microRNA-21-IN-1 |
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| T63879-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: microRNA-21-IN-1 |
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microRNA-21-IN-1 |
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| T63879-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: microRNA-21-IN-1 |
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 microRNA-21-IN-2 |
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| T61093-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: microRNA-21-IN-2 |
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microRNA-21-IN-2 |
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| T61093-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: microRNA-21-IN-2 |
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microRNA-21-IN-2 |
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| T61093-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: microRNA-21-IN-2 |
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microRNA-21-IN-2 |
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| T61093-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: microRNA-21-IN-2 |
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microRNA-21-IN-2 |
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| T61093-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: microRNA-21-IN-2 |
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 microRNA mimics |
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| GC0092 | GenCefe Co Ltd | 5 nmol/2 OD | EUR 48.95 |
 microRNA agomiR |
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| GC0096 | GenCefe Co Ltd | 5 nmol/2 OD | EUR 87.45 |
 microRNA inhibitor |
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| GC0093 | GenCefe Co Ltd | 10 nmol/2 OD | EUR 48.95 |
 microRNA antagomiR |
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| GC0097 | GenCefe Co Ltd | 10 nmol/2 OD | EUR 87.45 |
 Spike-In Kit) microRNA (cel-miR-39) Spike-In Kit |
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| 59000 | Norgen Biotek Corp | 1 Kit | EUR 33 |
) pGreenPuro Scramble Hairpin Control - Virus (for shRNAs and miRZips) |
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| MZIP000-VA-1 | SBI | >1 x 10^6 IFUs | EUR 652 |
 microRNA mimics N.C |
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| GC0094 | GenCefe Co Ltd | 5 nmol/2 OD | EUR 31.05 |
 microRNA agomiR N.C |
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| GC0098 | GenCefe Co Ltd | 5 nmol/2 OD | EUR 58.05 |
 microRNA inhibitor N.C |
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| GC0095 | GenCefe Co Ltd | 10 nmol/2 OD | EUR 31.05 |
 microRNA antagomiR N.C |
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| GC0099 | GenCefe Co Ltd | 10 nmol/2 OD | EUR 58.05 |
 microRNA Purification Kit |
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| 21300 | Norgen Biotek Corp | 25 Preps | EUR 149.4 |
 MicroRNA-Isolation-Kit |
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| KS341025 | Biochain | 1 kit | EUR 208.6 |
 Cancer MicroRNA qPCR Array |
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| RA610A-1 | SBI | 10 profiles | EUR 1406.4 |
 Plant MicroRNA Purification Kit |
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| 10760135-1 | Bio-WORLD | 25 Prep(s) | EUR 316.11 |
 Plant microRNA Purification Kit |
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| 54700 | Norgen Biotek Corp | 25 Preps | EUR 149.4 |
 Urine microRNA Purification Kit |
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| 29000 | Norgen Biotek Corp | 25 Preps | EUR 167.4 |
 Human microRNA-210-miR-210-ELISA |
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| QY-E05678 | Qayee Biotechnology | 96T | EUR 400 |
 ELISA Kit) Human MicroRNA-210 (miR-210) ELISA Kit |
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| MBS3800168-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human MicroRNA-210 (miR-210) ELISA Kit |
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| MBS3800168-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human MicroRNA-210 (miR-210) ELISA Kit |
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| MBS3800168-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human MicroRNA-210 (miR-210) ELISA Kit |
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| MBS3800168-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
 ELISA Kit) Human microrna-21(mir-21) ELISA Kit |
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| SL3405Hu | Sunlong | 96 Tests | EUR 468 |
 microScript microRNA cDNA Synthesis Kit |
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| 54410 | Norgen Biotek Corp | 50 Reactions | EUR 219 |
microScript microRNA cDNA Synthesis Kit |
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| 54415 | Norgen Biotek Corp | 12 Reactions | EUR 53.4 |
 Stem Cell MicroRNA Profiling Panel |
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| RA620A-1 | SBI | 10 profiles | EUR 1406.4 |
 SanPrep Column microRNA Miniprep Kit |
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| SK8811 | Bio Basic | 50prep | EUR 151.32 |
 MicroRNA Precursor Pooled Plasmid Library |
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| PMIRHPLPA-1 | SBI | 1 aliquot plasmid DNA | EUR 60 |
) Osseous Tissue microRNA Kit(Spin Column) |
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| 2151A | Unibiotest | 50 Tests | EUR 500 |
Osseous Tissue microRNA Kit(Spin Column) |
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| 2151B | Unibiotest | 4*50 Tests | EUR 1500 |
 Expression Plasmid of Rat microRNA MIR1 |
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| SC403107 | Origene Technologies GmbH | 10 µg | Ask for price |
) Scramble control hairpin in pCDH-CMV-MCS-EF1-copGFP (CD511B-1) |
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| PMIRH000PA-1 | SBI | Bacterial Streak | EUR 594 |
 Expression Plasmid of Rat microRNA MIR16 |
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| SC403169 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR21 |
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| SC403219 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR22 |
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| SC403234 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR25 |
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| SC403243 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR28 |
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| SC403248 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR32 |
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| SC403286 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR33 |
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| SC403296 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR93 |
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| SC403522 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR96 |
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| SC403524 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR98 |
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| SC403525 | Origene Technologies GmbH | 10 µg | Ask for price |
 rno-miRNome MicroRNA Profiling Kit [Rat] |
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| RA680B-1 | SBI | 20 complete profiles | EUR 2006.4 |
 Expression Plasmid of Rat microRNA MIR100 |
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| SC403108 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR105 |
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| SC403113 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR107 |
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| SC403115 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR10a |
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| SC403116 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR10b |
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| SC403117 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR122 |
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| SC403121 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR127 |
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| SC403132 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR132 |
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| SC403141 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR134 |
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| SC403145 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR136 |
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| SC403148 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR137 |
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| SC403149 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR139 |
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| SC403152 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR140 |
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| SC403153 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR141 |
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| SC403154 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR142 |
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| SC403155 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR143 |
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| SC403156 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR144 |
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| SC403157 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR145 |
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| SC403158 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR147 |
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| SC403161 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR150 |
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| SC403163 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR151 |
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| SC403164 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR152 |
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| SC403165 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR153 |
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| SC403166 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR154 |
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| SC403167 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR15b |
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| SC403168 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR183 |
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| SC403178 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR184 |
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| SC403180 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR185 |
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| SC403182 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR186 |
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| SC403183 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR187 |
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| SC403184 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR188 |
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| SC403185 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR18a |
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| SC403186 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR192 |
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| SC403192 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR193 |
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| SC403193 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR195 |
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| SC403196 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR19a |
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| SC403201 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR201 |
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| SC403207 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR202 |
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| SC403208 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR204 |
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| SC403211 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR205 |
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| SC403212 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR206 |
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| SC403213 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR207 |
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| SC403214 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR20a |
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| SC403217 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR20b |
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| SC403218 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR210 |
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| SC403220 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR211 |
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| SC403221 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR212 |
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| SC403222 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR214 |
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| SC403223 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR215 |
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| SC403224 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR217 |
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| SC403227 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR221 |
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| SC403235 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR222 |
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| SC403236 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR223 |
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| SC403237 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR224 |
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| SC403238 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR23a |
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| SC403239 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR23b |
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| SC403240 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR26a |
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| SC403244 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR26b |
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| SC403245 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR27a |
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| SC403246 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR27b |
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| SC403247 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR290 |
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| SC403249 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR292 |
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| SC403252 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR293 |
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| SC403253 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR294 |
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| SC403254 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR296 |
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| SC403257 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR297 |
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| SC403258 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR298 |
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| SC403259 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR29a |
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| SC403263 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR29c |
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| SC403266 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR300 |
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| SC403267 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR30a |
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| SC403277 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR30d |
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| SC403280 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR30e |
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| SC403281 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR31a |
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| SC403284 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR31b |
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| SC403285 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR320 |
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| SC403287 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR322 |
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| SC403288 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR323 |
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| SC403289 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR324 |
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| SC403290 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR325 |
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| SC403291 | Origene Technologies GmbH | 10 µg | Ask for price |
 Expression Plasmid of Rat microRNA MIR326 |
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| SC403292 | Origene Technologies GmbH | 10 µg | Ask for price |
placenta-derived exosomes play an important role in cellular communication both in the mother and fetus. concentration and their composition is modified in some disorders of pregnancy, such as gestational diabetes mellitus (GDM). Isolation and characterization of placental exosomes from serum, plasma and tissue from patients with GDM have been described previously; However, to the best of our knowledge, to date, no studies are available on placental exosomes isolated from the urine of patients with GDM.