Expression profile of microRNAs in the testes of patients with Klinefelter syndrome

Klinefelter syndrome (KS) is the most common sex chromosome aneuploidy. Typical characteristics of KS is oligozoospermia. Although several studies have described the natural history of the degenerative process germ cells in patients with KS, the molecular mechanisms that initiate this process is not well marked.

MicroRNA (miRNA) -mediated post-transcriptional control mechanisms has been increasingly recognized as an important regulator of spermatogenesis; However, only a few studies have evaluated the role of miRNAs in gonadal failure patients.

Here, we describe the differential expression profiles of miRNAs in samples of testicular tissue taken from patients with KS. We analyzed samples of testicular tissue from 4 KS patients and 5 control patients (obstructive azoospermia) through generation sequencing, which can provide information about the mechanisms involved in the degeneration of germ cells. Typical differential expression profiles for 166 miRNAs identified in KS patients: 66 were upregulated and 100 downregulated.

A interactome analysis conducted for 7 of the 20 miRNAs upregulated and downregulated. The results showed that the target gene is involved in the development process, proliferation, and differentiation of spermatogenesis, which may explain their role in the development of infertility. This is the first report of a miRNA expression profiles generated from samples of testicular tissue KS patients.

 Expression profile of microRNAs in the testes of patients with Klinefelter syndrome
Expression profile of microRNAs in the testes of patients with Klinefelter syndrome

MicroRNA profiles altered in neonatal pigs following the milk glands after giving birth to a nursing infant formula

Postnatal dietary modulation of microRNAs (miRNAs) and the effect on miRNA-mRNA interactions in tissues remains unknown. This study aimed to investigate whether dietary factors (formula vs. breastfeeding) affected milk miRNA expression and to determine whether these changes coincide with changes in mammary gland development in neonatal piglets. Female Yorkshire / Duroc pig pigs fed milk or milk- or soy-based infant formula milk cow (from postnatal day 2 days 21; n = 6 / group).

Different miRNAs expressed milk is determined by using miRNA profiles, followed by miRNA and mRNA expression characterized by reverse-transcription quantitative polymerase chain reaction. Milk and soy formulas reduce the expression of miR-1, -128, -133a, -193b, -206 and -27a; Mirna modified mRNA down-regulation of gene expression (eg, Ccnd1, Tgfb3, Igf1r and Tbx3) consistent with increased cell proliferation and reduced apoptosis in the developing mammary gland.

Interestingly, down-regulation of miR-1, -128 and -27a also correlates with increased gene mRNA encoding such Hmgcr Hmgcs and cholesterol synthesis in the mammary gland in response to lower levels of cholesterol circulating. feeding formula milk affected miRNA profile in neonatal pigs, along with increased cell proliferation and gene expression of cholesterol synthesis, indicating the beginning of the nutritional modulation of miRNAs can contribute to the regulation of cholesterol homeostasis status and the proliferation of mammary glands develop during infancy.

PB-CMV-GreenPuro Scramble Hairpin Control Vector

PBSI505-000PA-1 10 ug
EUR 625

pMC.CMV-GFP-T2A-Puro-H1-Scramble (shRNA scramble control parental minicircle plasmid)

MNSI000A-1 10 ug
EUR 779

pGreenPuro Scramble Hairpin Control - Construct (for shRNAs and miRZips)

MZIP000-AA-1 Miniprep DNA
EUR 620

pGreenPuro Scramble Hairpin Control - Construct (for shRNAs and miRZips)

MZIP000-PA-1 Bacterial Streak
EUR 594

MicroRNA Isolation Kit

KS341025 1 kit
EUR 247

Cancer MicroRNA qPCR Array

RA610A-1 10 profiles
EUR 1406.4

Human microRNA-210(miR-210)ELISA

QY-E05678 96T
EUR 433.2

Plant MicroRNA Purification Kit

10760135-1 25 Prep(s)
EUR 245.48

Human microrna-21(mir-21) ELISA Kit

SL3405Hu 96 Tests
EUR 468

Stem Cell MicroRNA Profiling Panel

RA620A-1 10 profiles
EUR 1406.4

SanPrep Column microRNA Miniprep Kit

SK8811 50prep
EUR 151.32

MicroRNA Precursor Pooled Plasmid Library

PMIRHPLPA-1 1 aliquot plasmid DNA
EUR 60

rno-miRNome MicroRNA Profiling Kit [Rat]

RA680B-1 20 complete profiles
EUR 2006.4

ZIP (SCRAMBLED)

A8830-1 1 mg
EUR 188.4
Description: IC50: By suppressing protein kinase M? (PKM?), ZIP reverses late-phase LTP with an IC50 of 1 - 2.5 ?M.Long-term potentiation (LTP), a persistent synaptic enhancement, is considered to be a substrate for memory.

hsa-miRNome MicroRNA Profiling Kit [Human]

RA660A-1 20 profiles
EUR 2212.8

mmu-miRNome MicroRNA Profiling Kit [Mouse]

RA670A-1 20 profiles
EUR 2046

LL-37 (scrambled)

H-7886.0500 0.5mg
EUR 339.6
Description: Sum Formula: C205H340N60O53; CAS# [1354065-56-7] net

LL-37 (scrambled)

H-7886.1000 1.0mg
EUR 529.2
Description: Sum Formula: C205H340N60O53; CAS# [1354065-56-7] net

miRZip-1 anti-miR-1 microRNA construct

MZIP1-PA-1 Bacterial Streak
EUR 620

miRZip-7 anti-miR-7 microRNA construct

MZIP7-PA-1 Bacterial Streak
EUR 620

miRZip-9 anti-miR-9 microRNA construct

MZIP9-PA-1 Bacterial Streak
EUR 620

Scrambled 10Panx

A2701-1 1 mg
EUR 129.6
Description: Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents.

Scrambled 10Panx

A2701-10 10 mg
EUR 309.6
Description: Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents.

Scrambled 10Panx

A2701-25 25 mg
EUR 616.8
Description: Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents.

Scrambled 10Panx

A2701-5 5 mg
EUR 199.2
Description: Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents.

miRZip-16 anti-miR-16 microRNA construct

MZIP16-PA-1 Bacterial Streak
EUR 620

miRZip-17 anti-miR-17 microRNA construct

MZIP17-AA-1 Miniprep DNA
EUR 620

miRZip-17 anti-miR-17 microRNA construct

MZIP17-PA-1 Bacterial Streak
EUR 620

miRZip-21 anti-miR-21 microRNA construct

MZIP21-PA-1 Bacterial Streak
EUR 620

miRZip-22 anti-miR-22 microRNA construct

MZIP22-PA-1 Bacterial Streak
EUR 620

miRZip-24 anti-miR-24 microRNA construct

MZIP24-PA-1 Bacterial Streak
EUR 620

miRZip-25 anti-miR-25 microRNA construct

MZIP25-PA-1 Bacterial Streak
EUR 620

miRZip-31 anti-miR-31 microRNA construct

MZIP31-PA-1 Bacterial Streak
EUR 620

miRZip-32 anti-miR-32 microRNA construct

MZIP32-PA-1 Bacterial Streak
EUR 620

miRZip-93 anti-miR-93 microRNA construct

MZIP93-PA-1 Bacterial Streak
EUR 620

miRZip-95 anti-miR-95 microRNA construct

MZIP95-PA-1 Bacterial Streak
EUR 620

miRZip-96 anti-miR-96 microRNA construct

MZIP96-PA-1 Bacterial Streak
EUR 620

miRZip-98 anti-miR-98 microRNA construct

MZIP98-PA-1 Bacterial Streak
EUR 620

MicroRNA precursor pooled library, HT prepackaged

PMIRHPLVAHT-1 10 virus aliquots
EUR 9763

5-FAM-LL-37 (scrambled)

H-7888.0500 0.5mg
EUR 559.2
Description: Sum Formula: C226H350N60O59; CAS# [2022972-73-0] net

5-FAM-LL-37 (scrambled)

H-7888.1000 1.0mg
EUR 931.2
Description: Sum Formula: C226H350N60O59; CAS# [2022972-73-0] net

miRZip-100 anti-miR-100 microRNA construct

MZIP100-PA-1 Bacterial Streak
EUR 620

miRZip-101 anti-miR-101 microRNA construct

MZIP101-PA-1 Bacterial Streak
EUR 620

miRZip-103 anti-miR-103 microRNA construct

MZIP103-PA-1 Bacterial Streak
EUR 620

miRZip-107 anti-miR-107 microRNA construct

MZIP107-PA-1 Bacterial Streak
EUR 620

miRZip-10a anti-miR-10a microRNA construct

MZIP10a-PA-1 Bacterial Streak
EUR 620

miRZip-10b anti-miR-10b microRNA construct

MZIP10b-PA-1 Bacterial Streak
EUR 620

miRZip-122 anti-miR-122 microRNA construct

MZIP122-PA-1 Bacterial Streak
EUR 620

miRZip-124 anti-miR-124 microRNA construct

MZIP124-PA-1 Bacterial Streak
EUR 620

miRZip-128 anti-miR-128 microRNA construct

MZIP128-PA-1 Bacterial Streak
EUR 620

miRZip-132 anti-miR-132 microRNA construct

MZIP132-PA-1 Bacterial Streak
EUR 620

miRZip-134 anti-miR-134 microRNA construct

MZIP134-PA-1 Bacterial Streak
EUR 620

miRZip-136 anti-miR-136 microRNA construct

MZIP136-PA-1 Bacterial Streak
EUR 620

miRZip-137 anti-miR-137 microRNA construct

MZIP137-PA-1 Bacterial Streak
EUR 620

miRZip-138 anti-miR-138 microRNA construct

MZIP138-PA-1 Bacterial Streak
EUR 620

miRZip-141 anti-miR-141 microRNA construct

MZIP141-PA-1 Bacterial Streak
EUR 620

miRZip-143 anti-miR-143 microRNA construct

MZIP143-PA-1 Bacterial Streak
EUR 620

miRZip-144 anti-miR--144 microRNA construct

MZIP144-PA-1 Bacterial Streak
EUR 620

miRZip-145 anti-miR-145 microRNA construct

MZIP145-PA-1 Bacterial Streak
EUR 620

miRZip-147 anti-miR-147 microRNA construct

MZIP147-PA-1 Bacterial Streak
EUR 620

miRZip-149 anti-miR-149 microRNA construct

MZIP149-PA-1 Bacterial Streak
EUR 620

miRZip-150 anti-miR-150 microRNA construct

MZIP150-PA-1 Bacterial Streak
EUR 620

miRZip-152 anti-miR-152 microRNA construct

MZIP152-PA-1 Bacterial Streak
EUR 620

miRZip-153 anti-miR-153 microRNA construct

MZIP153-PA-1 Bacterial Streak
EUR 620

miRZip-154 anti-miR-154 microRNA construct

MZIP154-PA-1 Bacterial Streak
EUR 620

miRZip-155 anti-miR-155 microRNA construct

MZIP155-PA-1 Bacterial Streak
EUR 620

miRZip-15a anti-miR-15a microRNA construct

MZIP15a-PA-1 Bacterial Streak
EUR 620

miRZip-15b anti-miR-15b microRNA construct

MZIP15b-PA-1 Bacterial Streak
EUR 620

miRZip-182 anti-miR-182 microRNA construct

MZIP182-AA-1 Miniprep DNA
EUR 620

miRZip-182 anti-miR-182 microRNA construct

MZIP182-PA-1 Bacterial Streak
EUR 620

miRZip-183 anti-miR-183 microRNA construct

MZIP183-PA-1 Bacterial Streak
EUR 620

miRZip-184 anti-miR-184 microRNA construct

MZIP184-PA-1 Bacterial Streak
EUR 620

miRZip-185 anti-miR-185 microRNA construct

MZIP185-PA-1 Bacterial Streak
EUR 620

miRZip-186 anti-miR-186 microRNA construct

MZIP186-PA-1 Bacterial Streak
EUR 620

miRZip-187 anti-miR-187 microRNA construct

MZIP187-PA-1 Bacterial Streak
EUR 620

miRZip-18a anti-miR-18a microRNA construct

MZIP18a-PA-1 Bacterial Streak
EUR 620

miRZip-18b anti-miR-18b microRNA construct

MZIP18b-PA-1 Bacterial Streak
EUR 620

miRZip-190 anti-miR-190 microRNA construct

MZIP190-PA-1 Bacterial Streak
EUR 620

miRZip-192 anti-miR-192 microRNA construct

MZIP192-PA-1 Bacterial Streak
EUR 620

miRZip-194 anti-miR-194 microRNA construct

MZIP194-PA-1 Bacterial Streak
EUR 620

miRZip-195 anti-miR-195 microRNA construct

MZIP195-PA-1 Bacterial Streak
EUR 620

miRZip-198 anti-miR-198 microRNA construct

MZIP198-PA-1 Bacterial Streak
EUR 620

miRZip-19a anti-miR-19a microRNA construct

MZIP19a-PA-1 Bacterial Streak
EUR 620

miRZip-19b anti-miR-19b microRNA construct

MZIP19b-PA-1 Bacterial Streak
EUR 620

miRZip-202 anti-miR-202 microRNA construct

MZIP202-PA-1 Bacterial Streak
EUR 620

miRZip-203 anti-miR-203 microRNA construct

MZIP203-PA-1 Bacterial Streak
EUR 620

miRZip-204 anti-miR-204 microRNA construct

MZIP204-PA-1 Bacterial Streak
EUR 620

miRZip-205 anti-miR-205 microRNA construct

MZIP205-PA-1 Bacterial Streak
EUR 620

miRZip-206 anti-miR-206 microRNA construct

MZIP206-PA-1 Bacterial Streak
EUR 620

miRZip-20a anti-miR-20a microRNA construct

MZIP20a-PA-1 Bacterial Streak
EUR 620

miRZip-20b anti-miR-20b microRNA construct

MZIP20b-PA-1 Bacterial Streak
EUR 620

miRZip-210 anti-miR-210 microRNA construct

MZIP210-PA-1 Bacterial Streak
EUR 620

miRZip-211 anti-miR-211 microRNA construct

MZIP211-PA-1 Bacterial Streak
EUR 620

miRZip-214 anti-miR-214 microRNA construct

MZIP214-AA-1 Miniprep DNA
EUR 620

miRZip-214 anti-miR-214 microRNA construct

MZIP214-PA-1 Bacterial Streak
EUR 620

miRZip-217 anti-miR-217 microRNA construct

MZIP217-PA-1 Bacterial Streak
EUR 620

miRZip-218 anti-miR-218 microRNA construct

MZIP218-PA-1 Bacterial Streak
EUR 620

miRZip-221 anti-miR-221 microRNA construct

MZIP221-PA-1 Bacterial Streak
EUR 620

miRZip-222 anti-miR-222 microRNA construct

MZIP222-PA-1 Bacterial Streak
EUR 620

miRZip-223 anti-miR-223 microRNA construct

MZIP223-PA-1 Bacterial Streak
EUR 620

miRZip-224 anti-miR-224 microRNA construct

MZIP224-PA-1 Bacterial Streak
EUR 620

miRZip-23a anti-miR-23a microRNA construct

MZIP23a-PA-1 Bacterial Streak
EUR 620

miRZip-23b anti-miR-23b microRNA construct

MZIP23b-PA-1 Bacterial Streak
EUR 620

miRZip-26a anti-miR-26a microRNA construct

MZIP26a-PA-1 Bacterial Streak
EUR 620

miRZip-26b anti-miR-26b microRNA construct

MZIP26b-PA-1 Bacterial Streak
EUR 620

miRZip-27a anti-miR-27a microRNA construct

MZIP27a-PA-1 Bacterial Streak
EUR 620

miRZip-27b anti-miR-27b microRNA construct

MZIP27b-PA-1 Bacterial Streak
EUR 620

miRZip-29a anti-miR-29a microRNA construct

MZIP29a-PA-1 Bacterial Streak
EUR 620

miRZip-29b anti-miR-29b microRNA construct

MZIP29b-PA-1 Bacterial Streak
EUR 620

miRZip-29c anti-miR-29c microRNA construct

MZIP29c-PA-1 Bacterial Streak
EUR 620

miRZip-30a anti-miR-30a microRNA construct

MZIP30a-PA-1 Bacterial Streak
EUR 620

miRZip-30b anti-miR-30b microRNA construct

MZIP30b-PA-1 Bacterial Streak
EUR 620

miRZip-30c anti-miR-30c microRNA construct

MZIP30c-PA-1 Bacterial Streak
EUR 620

miRZip-30d anti-miR-30d microRNA construct

MZIP30d-PA-1 Bacterial Streak
EUR 620

miRZip-30e anti-miR-30e microRNA construct

MZIP30e-PA-1 Bacterial Streak
EUR 620

miRZip-326 anti-miR-326 microRNA construct

MZIP326-PA-1 Bacterial Streak
EUR 620

miRZip-335 anti-miR-335 microRNA construct

MZIP335-AA-1 Miniprep DNA
EUR 620

miRZip-335 anti-miR-335 microRNA construct

MZIP335-PA-1 Bacterial Streak
EUR 620

miRZip-338 anti-miR-338 microRNA construct

MZIP338-5p-PA-1 Bacterial Streak
EUR 620

miRZip-33a anti-miR-33a microRNA construct

MZIP33a-AA-1 Miniprep DNA
EUR 620

miRZip-33a anti-miR-33a microRNA construct

MZIP33a-PA-1 Bacterial Streak
EUR 620

miRZip-33b anti-miR-33b microRNA construct

MZIP33b-PA-1 Bacterial Streak
EUR 620

miRZip-340 anti-miR-340 microRNA construct

MZIP340-PA-1 Bacterial Streak
EUR 620

miRZip-34a anti-miR-34a microRNA construct

MZIP34a-PA-1 Bacterial Streak
EUR 620

miRZip-365 anti-miR-365 microRNA construct

MZIP365-PA-1 Bacterial Streak
EUR 620

miRZip-367 anti-miR-367 microRNA construct

MZIP367-PA-1 Bacterial Streak
EUR 620

miRZip-372 anti-miR-372 microRNA construct

MZIP372-PA-1 Bacterial Streak
EUR 620

miRZip-373 anti-miR-373 microRNA construct

MZIP373-PA-1 Bacterial Streak
EUR 620

miRZip-375 anti-miR-375 microRNA construct

MZIP375-PA-1 Bacterial Streak
EUR 620

miRZip-377 anti-miR-377 microRNA construct

MZIP377-PA-1 Bacterial Streak
EUR 620

miRZip-378 anti-miR-378 microRNA construct

MZIP378-PA-1 Bacterial Streak
EUR 620


placenta-derived exosomes play an important role in cellular communication both in the mother and fetus. concentration and their composition is modified in some disorders of pregnancy, such as gestational diabetes mellitus (GDM). Isolation and characterization of placental exosomes from serum, plasma and tissue from patients with GDM have been described previously; However, to the best of our knowledge, to date, no studies are available on placental exosomes isolated from the urine of patients with GDM.