Treatment with Tang-luo-ning altered the microRNA expression profile in rats with diabetic peripheral neuropathy

Tang-luo-ning (TLN) is a traditional Chinese herbal recipe that has been used to treat diabetic peripheral neuropathy (DPN); However, the underlying mechanisms are still unclear. This study aims to investigate microRNA (miRNA) expression profiles in diabetic rats treated with TLN, and the predicted target genes. Male Sprague-Dawley rats were randomly divided into control, diabetes, and TLN-treated diabetic groups. Diabetes was induced with streptozotocin, and TLN (5 g / kg / day) orally administered for eight weeks.

Then, the sciatic nerve is harvested for miRNA microarray analysis. The differentially expressed miRNAs and their target genes analyzed. Compared with control mice, 24 miRNAs were significantly upregulated and 59 were downregulated in the sciatic nerves of diabetic mice with more than two-fold (all P <0.05). On TLN-treated diabetic mice, 26 miRNAs were upregulated and 14 downregulated compared with diabetic mice without treatment TLN (all P <0.05). DPN-induced changes of miRNA profiles TLN reversed with treatment.

A total of 1,402 of the target genes screened. In the GO analysis, gene localization, cytoplasm, and the enriched protein binding, and the most significantly enriched including neurotrophin, Fc epsilon RI, and the Wnt signaling pathway. Further analysis revealed that DVL1 and NTF3 genes involved in this pathway. Our findings suggest that TLN can affect Wnt and neurotrophin pathway by acting on the genes DVL1 and NTF3.

 Treatment with Tang-luo-ning altered the microRNA expression profile in rats with diabetic peripheral neuropathy
Treatment with Tang-luo-ning altered the microRNA expression profile in rats with diabetic peripheral neuropathy

Find signatures of lupus-related microRNA profile in the Gene Expression Omnibus repository

Lupus is one of the most common autoimmune disease systemic. It is a multifactorial disease that is genetic, epigenetic and environment plays a significant role. The pathogenesis of lupus is not well understood. However, deregulation of microRNAs (miRNAs) – one of the post-transcriptional regulators of gene – may contribute to the development of autoimmune disease.

Over the past two decades, advances in miRNA profiling using microarray has received a lot of attention, and it has been demonstrated that miRNAs play a regulatory role in the pathogenesis of lupus. Therefore, dysregulated miRNAs can be considered as a promising diagnostic biomarker for lupus. This article is an overview of lupus-related miRNA array profiles and studies in the Gene Expression Omnibus (GEO) database. The aim of our research is to expand the current knowledge dysregulated miRNAs known as a potential biomarker of SLE and to introduce a bioinformatics approach to using microarray data and find novel miRNA and gene candidates for further study. We identified HSA-miR-4709-5p, HSA-mir-140, mir-145-HSA, HSA-mir-659, mir-134-HSA, HSA-mir-150, mir-584-HSA, HSA-Mirza HSA-409 and miR-152 as a potential biomarker with integrated bioinformatics analysis.

miRNA Isolation Kit

FYG304-100P 100 Preps Ask for price

Endosome Isolation Kit

P528 - Ask for price

Mitochondria Isolation Kit

AR0156 1 kit
EUR 127.2

Preadipocyte Isolation Kit

K583-5 each
EUR 639.6

Urine DNA Isolation Kit

K5011150 1 kit
EUR 237

Stool DNA Isolation Kit

K5011250 1 kit
EUR 237

Serum DNA Isolation Kit

K5018100 1 kit
EUR 355

Total RNA Isolation Kit

P-9100 50 samples
EUR 416.7

Saliva DNA Isolation Kit

K5011050 1 kit
EUR 237

Genomic DNA Isolation Kit

55R-1362 50 assays
EUR 462
Description: Genomic DNA Isolation Kit for use in the research laboratory

Easy3-RNA Isolation Kit

FYG501-100P 100 Preps Ask for price

Easy3-RNA Isolation Kit

FYG501-500P 500 Preps Ask for price

Genomic DNA Isolation Kit

K281-50 each
EUR 326.4

Genomic DNA Isolation Kit

K2118-50 50 assays
EUR 385.2

Yeast Nuclei Isolation Kit

K289-50 each
EUR 470.4

Lipid Droplet Isolation Kit

MET-5011 50 preps
EUR 498
Description: Lipid droplets are lipid rich organelles found in the adipose tissue of eukaryotes. They function to regulate the hydrolysis and storage of neutral lipids and serve as storage for cholesterol and acyl-glycerols. Lipid droplets have also been associated with inflammatory responses, obesity, atherosclerosis, and cancer.

ExoPure? Isolation Kit   (Urine)

K1240-10 each
EUR 836.4

ExoPure? Isolation Kit   (Urine)

K1240-2 each
EUR 483.6

Cartilage RNA Isolation Kit

K2031010 1 kit
EUR 443

Apoptotic Cell Isolation Kit

55R-1349 30 units
EUR 874.8
Description: Apoptotic Cell Isolation Kit for use in the research laboratory

Apoptotic Cell Isolation Kit

K258-30 each
EUR 561.6

Total RNA Isolation Kit II

FATRS--001 100 preps
EUR 369.6

Total RNA Isolation Kit II

FATRS--050 50 preps
EUR 259.2

EVery EV RNA Isolation Kit

EVery100B-1 20 preps
EUR 412

Exo-Urine EV Isolation Kit

EXOU100A-1 2 x 5 reactions
EUR 490

FitAmp Gel DNA Isolation Kit

P-1007 100 Samples
EUR 324.48

Cell Mitochondria Isolation Kit

abx090630-50100tests 50-100 tests
EUR 309.6

Mitochondrial DNA Isolation Kit

55R-1361 50 assays
EUR 990
Description: Mitochondrial DNA Isolation Kit for use in the research laboratory

Mitochondrial DNA Isolation Kit

K280-50 each
EUR 705.6

Mitochondrial DNA Isolation Kit

K2117-50 50 assays
EUR 718.8

Rapid Blood RNA Isolation Kit

BT4182 10Preps
EUR 98.36

Rapid Blood RNA Isolation Kit

BT4183 50Preps
EUR 197.03

Rapid Blood RNA Isolation Kit

BT4184 250preps
EUR 608.1

Whole Blood DNA Isolation Kit

K528-100 each
EUR 451.2

Total RNA Isolation Kit (Plant)

P-9104 50 samples
EUR 416.7

Rapid Plant RNA Isolation Kit

PT4191 50Preps
EUR 95.63

Yeast Mitochondria Isolation Kit

K259-50 each
EUR 502.8

FitAmp Urine DNA Isolation Kit 

P-1017
  • EUR 474.12
  • EUR 171.60
  • EUR 292.60
  • 100 Samples
  • 50 Samples
  • 100 Samples

Total RNA Isolation Kit (Tissue)

P-9102 50 samples
EUR 416.7

EpiMag Viral RNA Isolation Kit

P-9108-050 50 samples
EUR 152.9

XCF Exosomal DNA Isolation Kit

XCF200A-1 20 rxn
EUR 328

Tissue Mitochondria Isolation Kit

abx090631-50100assays 50-100 assays
EUR 309.6

Lysosome Isolation Kit (20 tests)

P534 - Ask for price

Exosome Isolation kit (for urine)

P120L - Ask for price

Exosome Isolation kit (for urine)

P120S - Ask for price

Easy3-Plant RNA Isolation Kit

FYG502-100P 100 Preps Ask for price

Easy3-Plant RNA Isolation Kit

FYG502-500P 500 Preps Ask for price

FastPure FFPE DNA Isolation Kit

DC105-01 50 rxns
EUR 75.2

CD19 Positive Cell Isolation Kit

78564-1 1 x 10^8 Cells
EUR 70
Description: The CD19 Positive Cell Isolation Kit is designed to magnetically separate CD19-expressing-cells from a complex immune cell population. This kit is optimized for the isolation of CD19 positive cells from normal human peripheral blood mononuclear cells (PBMCs). Cells are incubated with the antibody:bead complex and placed on a magnet for quick and easy separation. When placed on the magnet, CD19-positive cells will be immobilized along the side of the tube while undesired CD19-negative cells will remain in suspension for easy removal.

CD19 Positive Cell Isolation Kit

78564-2 1 x 10^9 Cells
EUR 630
Description: The CD19 Positive Cell Isolation Kit is designed to magnetically separate CD19-expressing-cells from a complex immune cell population. This kit is optimized for the isolation of CD19 positive cells from normal human peripheral blood mononuclear cells (PBMCs). Cells are incubated with the antibody:bead complex and placed on a magnet for quick and easy separation. When placed on the magnet, CD19-positive cells will be immobilized along the side of the tube while undesired CD19-negative cells will remain in suspension for easy removal.

Rapid Bacteria RNA Isolation Kit

BS8625 50Preps
EUR 95.63

Genoirse Plant DNA Isolation Kit

GR101083 50
EUR 223

ExoPure? Isolation Kit   (Cell Media)

K1237-10 each
EUR 796.8

ExoPure? Isolation Kit   (Cell Media)

K1237-2 each
EUR 470.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10 each
EUR 836.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2 each
EUR 483.6

Lipopolysaccharide (LPS) Isolation Kit

K438-10 each
EUR 333.6

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-10 each
EUR 836.4

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-2 each
EUR 470.4

Apoptotic DNA Ladder Isolation Kit

K170-50 each
EUR 561.6

Cell Surface Protein Isolation Kit

K295-10 each
EUR 601.2

Apoptotic DNA Ladder Isolation Kit

K2045-50 50 assays
EUR 602.4

Bacterial Genomic DNA Isolation Kit

K309-100 each
EUR 451.2

Blood and Serum DNA Isolation Kit

K5017100 1 kit
EUR 355

EZExtract? Core Histone Isolation Kit

K234-100 each
EUR 314.4

10-min. Single Cell Isolation Kit

P713-20 - Ask for price

MagIso NK Cell Isolation Kit, Human

WHK-B023 20 tests, 200 tests Ask for price

Circulating Nuleic Acid Isolation Kit

FACFK-050 50 preps
EUR 589.2

Circulating Nuleic Acid Isolation Kit

FACFK-100 100 preps
EUR 990

Detergent-Free Nuclei Isolation Kit

P524-2 - Ask for price

Detergent-Free Nuclei Isolation Kit

P524-20 - Ask for price

Detergent-Free Nuclei Isolation Kit

P524-80 - Ask for price

Broad Range Total RNA Isolation Kit

K1341050 1 kit
EUR 259

MagIso CD3 Cell Isolation Kit, Mouse

WHK-B009 20 tests, 200 tests Ask for price

Org Frontier? Chloroplast Isolation Kit

K468-10 each
EUR 666

MagIso CD90.2 Cell Isolation Kit, Mouse

WHK-B010 20 tests, 200 tests Ask for price

Easy3-Total NucleicAcid Isolation Kit

FYG504-100ML 100 ml Ask for price

Easy3-Total NucleicAcid Isolation Kit

FYG504-500ML 500 ml Ask for price

FitAmp Plasma/Serum DNA Isolation Kit 

P-1004
  • EUR 416.70
  • EUR 149.60
  • EUR 253.00
  • 100 Samples
  • 50 Samples
  • 100 Samples

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-10 each
EUR 901.2

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-2 each
EUR 510

Exosome Isolation kit (for serum & plasma)

P101 - Ask for price

Exosome Isolation kit (for serum & plasma)

P101L - Ask for price

Exosome Isolation kit (for serum & plasma)

P101S - Ask for price

Rapid Fungal Genomic DNA Isolation Kit

FT71415 50Preps
EUR 91.97

Plant Tissue Genomic DNA Isolation Kit

K316-100 each
EUR 451.2

MagIso CX3CR1 Cell Isolation Kit, Mouse

WHK-B017 10 tests, 100 tests Ask for price

OrgFrontier? Plasma Membrane Isolation Kit

K414-10 each
EUR 679.2

Easy3-Plant Genomic DNA Isolation Kit

FYG503-100P 100 Preps Ask for price

Easy3-Plant Genomic DNA Isolation Kit

FYG503-500P 500 Preps Ask for price

MagIso CD4 T Cell Isolation Kit, Human

WHK-B001 10 tests
EUR 724.8

MagIso CD8 T Cell Isolation Kit, Human

WHK-B002 10 tests
EUR 724.8

MagIso CD4 T Cell Isolation Kit, Mouse

WHK-B003 10 tests
EUR 724.8

MagIso CD8 T Cell Isolation Kit, Mouse

WHK-B004 10 tests
EUR 724.8

MagIso Pan B Cell Isolation Kit, Mouse

WHK-B013 20 tests, 200 tests Ask for price

MagIso Pan B Cell Isolation Kit, Human

WHK-B022 20 tests, 200 tests Ask for price

Rapid Bacteria Genomic DNA Isolation Kit

BS8225 50Preps
EUR 91.97

Human Whole Blood Monocyte Isolation Kit

K933-30 each
EUR 451.2

Mammalian Cell Genomic DNA Isolation Kit

K967-100 each
EUR 457.2

EpiQuik Magbeads Quick RNA Isolation Kit

P-9106-050 50 samples
EUR 163.9

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-3 each
EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-5 each
EUR 796.8

Exosome Isolation kit (forHuman Body Fluid)

P121 - Ask for price

Exosome Isolation kit (forHuman Body Fluid)

P121L - Ask for price

Exosome Isolation kit (forHuman Body Fluid)

P121S - Ask for price

MagIso Naïve B Cell Isolation Kit, Human

WHK-B024 20 tests, 200 tests Ask for price

Soil DNA Isolation Mini Kit (100prep)

FASOI-001-1 100 preps
EUR 241.2

Soil RNA Isolation Mini Kit (100prep)

FASRK-100 100 preps
EUR 224.4

MagIso Neutrophil Cell Isolation Kit, Mouse

WHK-B015 10 tests, 100 tests Ask for price

Soil DNA Isolation Mini Kit (50prep)

FASOI-001 50 preps
EUR 189.6

Soil DNA Isolation Midi Kit (24prep)

FASOI-002 24 preps
EUR 259.2

Soil RNA Isolation Mini Kit (50prep)

FASRK-001 50 preps
EUR 180

MagIso Pan B Cell Isolation Kit, Mouse Ⅱ

WHK-B012 20 tests, 200 tests Ask for price

PSEUDOMONAS ISOLATION AGAR

P16-114-10kg 10 kg
EUR 2058

PSEUDOMONAS ISOLATION AGAR

P16-114-2kg 2kg
EUR 494.4

PSEUDOMONAS ISOLATION AGAR

P16-114-500g 500 g
EUR 177.6

FastPure FFPE DNA Isolation Mini Kit

DC105 50 rxn
EUR 241.2

EpiQuik Total RNA Isolation Fast Kit

P-9105-050 50 samples
EUR 176

EpiQuik Viral RNA Isolation Fast Kit

P-9107-050 50 samples
EUR 167.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1030-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1030-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3 each
EUR 529.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1030-5 each
EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1031-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1031-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1031-5 each
EUR 796.8

Exosome Isolation kit (for cell culture media)

P100 - Ask for price

Exosome Isolation kit (for cell culture media)

P100L - Ask for price

Exosome Isolation kit (for cell culture media)

P100S - Ask for price

FastPure Cell/Tissue Total RNA Isolation Kit

RC101 50 rxn
EUR 274.8

MagIso Pan Monocyte Cell Isolation Kit, Human

WHK-B021 20 tests, 200 tests Ask for price

PSEUDOMONAS ISOLATION BROTH

P16-115-10kg 10 kg Ask for price

PSEUDOMONAS ISOLATION BROTH

P16-115-2Kg 2 Kg Ask for price

PSEUDOMONAS ISOLATION BROTH

P16-115-500g 500 g Ask for price

FastPure Plant DNA Isolation Mini Kit

DC104 50 rxn
EUR 192

FastPure Plant DNA Isolation Mini Kit

DC104-01 50 rxns
EUR 60

10x Cell Isolation Buffer

78563 5 ml
EUR 25
Description: This buffer is intended for use with mammalian cells during magnetic cell isolation or single cell processing. This buffer is optimized and formulated to reduce nonspecific binding and cell clumping

One-Tube Bacteria Genomic DNA Isolation Kit

BS8413 100preps
EUR 94.72

One-Tube Bacteria Genomic DNA Isolation Kit

BS8414 500Preps, 500prep
EUR 198.85

MagIso Pan Dendritic Cell Isolation Kit, Mouse

WHK-B011 20 tests, 200 tests Ask for price

MagIso CD8 Naïve T Cell Isolation Kit, Mouse

WHK-B018 20 tests, 200 tests Ask for price

MagIso CD4 Naïve T Cell Isolation Kit, Mouse

WHK-B019 20 tests, 200 tests Ask for price

MagIso CD8 Naïve T Cell Isolation Kit, Human

WHK-B025 20 tests, 200 tests Ask for price

MagIso CD4 Naïve T Cell Isolation Kit, Human

WHK-B027 20 tests, 200 tests Ask for price

MagIso B Cell (CD43-) Cell Isolation Kit, Human

WHK-B030 20 tests, 200 tests Ask for price

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-50rxns 50 rxns
EUR 493.2

MagIso CD14+ Monocytes Cell Isolation Kit, Human

WHK-B029 10 tests, 100 tests Ask for price

MagIso CD8 Memory T Cell Isolation Kit, Human

WHK-B026 20 tests, 200 tests Ask for price

MagIso CD4 Memory T Cell Isolation Kit, Human

WHK-B028 20 tests, 200 tests Ask for price

8-min Intact Plant Chloroplast Isolation Kit

P511L - Ask for price

FitAmp General Tissue Section DNA Isolation Kit 

P-1003
  • EUR 754.26
  • EUR 253.00
  • EUR 490.60
  • 100 Samples
  • 50 Samples
  • 100 Samples

Soil DNA Plus Isolation Mini Kit (100prep)

FAPSO-001-1 100 preps
EUR 241.2

FitAmp Paraffin Tissue Section DNA Isolation Kit 

P-1009
  • EUR 702.06
  • EUR 239.80
  • EUR 454.30
  • 100 Samples
  • 50 Samples
  • 100 Samples

FastPure Universal Plant Total RNA Isolation Kit

RC411-01 50 rxns
EUR 100

Mitochondria Isolation Kit (Mammalian cells / tissues)

P507L - Ask for price

FastPure Bacteria DNA Isolation Mini Kit

DC103 100 rxn
EUR 212.4

FastPure Bacteria DNA Isolation Mini Kit

DC103-01 100 rxns
EUR 52

Easy-Exo Saliva Exosome Isolation Kit, 95% pure

P530 - Ask for price

Easy-Exo Saliva Exosome Isolation Kit, 95% pure

P530S - Ask for price

FastPure Cell/Tissue Total RNA Isolation Kit V2

RC112-01 50 rxns
EUR 82.6

Soil DNA Plus Isolation Mini Kit (50prep)

FAPSO-001 50 preps
EUR 189.6

RNA-easy Isolation Reagent

R701-01 100 ml
EUR 201.6

RNA-easy Isolation Reagent

R701-02 200 ml
EUR 254.4

EpiQuik Circulating Cell-Free DNA Isolation Kit

P-1064
  • EUR 416.70
  • EUR 148.50
  • EUR 253.00
  • 50 Isolations
  • 25 Isolations
  • 50 Isolations

FastPure Blood DNA Isolation Mini Kit V2

DC111-01 50 rxn
EUR 214.8

FastPure Blood DNA Isolation Mini Kit V2

DC111-02 200 rxn
EUR 472.8

Exosome Isolation kit (for stem cell culture media)

P107S - Ask for price

Exosome Isolation kit (for stem cell culture media)

P107 - Ask for price

MagIso Natural killer (NK) Cell Isolation Kit, Mouse

WHK-B014 20 tests, 200 tests Ask for price

ChromaFlash Chromatin Isolation & Shearing Kit 

P-2023
  • EUR 324.48
  • EUR 189.20
  • 100 Preperations
  • 100 Preparations

Albumin, cold alcohol isolation

A0903 1g
EUR 99.67

Tissue (Tumor) Dissociation / Single Cell Isolation Kit

P712-25 - Ask for price

Tissue (Tumor) Dissociation / Single Cell Isolation Kit

P712-4 - Ask for price

Tissue (Tumor) Dissociation / Single Cell Isolation Kit

P712-50 - Ask for price

Kinesis Rheodyne Isolation Seal

CHR2645 EACH
EUR 27.6

Kinesis Rheodyne Isolation Seal

CHR2791 EACH
EUR 46.8

FastPure Cell/Tissue DNA Isolation Mini Kit

DC102 100 rxn
EUR 212.4

FastPure Cell/Tissue DNA Isolation Mini Kit

DC102-01 100 rxns
EUR 52

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)

M1039-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)

M1039-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)

M1039-5 each
EUR 796.8

Nuclei and Cytosol Isolation Kit for Adipose Tissues

P529 - Ask for price

cfMAX™ cfDNA Isolation System

CFMAX100A-1 1 Kit
EUR 412

Human Whole Blood Polymorphonuclear Cell Isolation Kit

K483-30 each
EUR 451.2

ExoQuick ULTRA EV Isolation Kit for Serum and Plasma

EQULTRA-20A-1 20 reactions
EUR 941

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-10 - Ask for price

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-20 - Ask for price

Hipro Circulating Cell-Free DNA (cfDNA) Isolation Kit

W2603-50 - Ask for price

Mammalian Mitochondria Isolation Kit for Cultured Cells

20-abx098856
  • EUR 126.00
  • EUR 493.20
  • 2 rxns
  • 50 rxns

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)

M1032-10 each
EUR 1057.2

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)

M1032-20 each
EUR 1618.8


The diagnosis of obstructive sleep apnea (OSA) in Alzheimer’s disease (AD) by polysomnography (PSG) challenging because of the collaboration required of the patient. In addition, screening questionnaires have shown limited usefulness in this subpopulation. Considering this, we investigated circulating microRNA (miRNA) profiles associated with OSA in patients with AD. This study included a carefully selected group of females with mild-moderate AD is confirmed by biological evaluation (n = 29). Individuals submitted to one night PSG to diagnose (apnea-hypopnea index ≥ 15 / h) OSA and the blood collected in the next morning.